Proteinuria and progression of renal disease: therapeutic implications

RT Gansevoort, GJ Navis, FH Wapstra… - Current opinion in …, 1997 - journals.lww.com
RT Gansevoort, GJ Navis, FH Wapstra, PE de Jong, D de Zeeuw
Current opinion in nephrology and hypertension, 1997journals.lww.com
The relationship between proteinuria and progression of renal disease has long been an
issue of debate. The present review deals with some of the recent publications on this topic.
New concepts are emphasized: the possible causal role of proteinuria in the
pathophysiology of progressive renal function loss, and the decrease in urinary protein loss
at the beginning of renoprotective therapy as a predictor of renal function outcome during
this treatment.
Abstract
The relationship between proteinuria and progression of renal disease has long been an issue of debate. The present review deals with some of the recent publications on this topic. New concepts are emphasized: the possible causal role of proteinuria in the pathophysiology of progressive renal function loss, and the decrease in urinary protein loss at the beginning of renoprotective therapy as a predictor of renal function outcome during this treatment.
Lippincott Williams & Wilkins