[HTML][HTML] ADAMTS-1 protein anchors at the extracellular matrix through the thrombospondin type I motifs and its spacing region
K Kuno, K Matsushima - Journal of Biological Chemistry, 1998 - ASBMB
Cellular disintegrin and metalloproteinases (ADAMs) are a family of genes with a sequence
similar to those of snake venom metalloproteinases and disintegrins. The ADAMTS-1 gene
encodes a new type of ADAM protein with respect to possessing the thrombospondin (TSP)
type I motifs. Expression of the gene is induced in kidney and heart by in vivo administration
of lipopolysaccharide, suggesting a possible role in the inflammatory reaction. In this study,
we characterized the ADAMTS-1 gene product by using a transient expression system in …
similar to those of snake venom metalloproteinases and disintegrins. The ADAMTS-1 gene
encodes a new type of ADAM protein with respect to possessing the thrombospondin (TSP)
type I motifs. Expression of the gene is induced in kidney and heart by in vivo administration
of lipopolysaccharide, suggesting a possible role in the inflammatory reaction. In this study,
we characterized the ADAMTS-1 gene product by using a transient expression system in …