[PDF][PDF] The chemokine receptor CXCR4 is required for the retention of B lineage and granulocytic precursors within the bone marrow microenvironment

Q Ma, D Jones, TA Springer - Immunity, 1999 - cell.com
Immunity, 1999cell.com
We report that the chemokine receptor CXCR4 is required for the retention of B lineage and
granulocytic precursors within fetal liver and bone marrow microenvironment. In CXCR4-
deficient embryos, pro-B cells are present in blood but hardly detectable in liver; myeloid
cells are elevated in blood and reduced in liver compared to wild-type embryos. Mice
reconstituted with CXCR4-deficient fetal liver cells have reduced donor-derived mature B
lymphocytes in blood and lymphoid organs. The numbers of pro-B and pre-B cells are …
Abstract
We report that the chemokine receptor CXCR4 is required for the retention of B lineage and granulocytic precursors within fetal liver and bone marrow microenvironment. In CXCR4-deficient embryos, pro-B cells are present in blood but hardly detectable in liver; myeloid cells are elevated in blood and reduced in liver compared to wild-type embryos. Mice reconstituted with CXCR4-deficient fetal liver cells have reduced donor-derived mature B lymphocytes in blood and lymphoid organs. The numbers of pro-B and pre-B cells are reduced in bone marrow and abnormally high in blood. Granulocytic cells are reduced in bone marrow but elevated and less mature in the blood. B lineage and granulocytic precursors are released into the periphery in absence of CXCR4.
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