G-protein-coupled, extracellular Ca2+-sensing receptor: a versatile regulator of diverse cellular functions

EM Brown, PM Vassilev, S Quinn, SC Hebert - Vitamins & Hormones, 1998 - Elsevier
Publisher Summary This chapter examines the importance of G-protein-coupled,
extracellular Ca 2+-sensing receptor as a versatile regulator of diverse cellular functions. In
the extracellular space, calcium is a cofactor for clotting factors, adhesion molecules, and
other proteins. It also regulates neuronal excitability and is an essential component of the
mineral phase of the skeleton. Bone provides both a structural framework protecting crucial
bodily structures and enabling locomotion and a large reservoir of mineral ions that can be …