Immunoglobulin dysregulation in murine graft-vs-host disease: a hyper-IgE syndrome
HN Claman, HL Spiegelberg - Clinical Immunology and Immunopathology, 1990 - Elsevier
Immunoglobulin production, particularly IgE, is known to be dysregulated in graft-vs-host
disease (GVHD). We examined serum levels of the highly T-dependent Ig isotypes, IgE,
IgG1, and IgG2a, in two different mouse models of GVHD. GVHD across minor
histocompatibility barriers is produced by injection of B10. D2 spleen cells into 600 rad
irradiated BALB/c hosts. Both strains are H2d and mls b, but differ at the minor
histocompatibility antigens. As GVHD progresses there is a rapid rise in serum IgE (300-fold) …
disease (GVHD). We examined serum levels of the highly T-dependent Ig isotypes, IgE,
IgG1, and IgG2a, in two different mouse models of GVHD. GVHD across minor
histocompatibility barriers is produced by injection of B10. D2 spleen cells into 600 rad
irradiated BALB/c hosts. Both strains are H2d and mls b, but differ at the minor
histocompatibility antigens. As GVHD progresses there is a rapid rise in serum IgE (300-fold) …