Leptin receptor missense mutation in the fatty Zucker rat.
MS Phillips, LQY Liu QingYun, HA Hammond, V Dugan… - 1996 - cabidigitallibrary.org
MS Phillips, LQY Liu QingYun, HA Hammond, V Dugan, PJ Hey, CT Caskey, JF Hess
1996•cabidigitallibrary.orgThe discovery of leptin, a peptide hormone synthesized in adipocytes, has led to the
identification of a novel signal transduction pathway involved in the control of body weight.
This letter describes a missense mutation in the rat leptin receptor gene (OB-R) that is
thought to represent the fatty mutation (fa). Amino acid sequence alignments are presented
for human, rat and mouse OB-R.
identification of a novel signal transduction pathway involved in the control of body weight.
This letter describes a missense mutation in the rat leptin receptor gene (OB-R) that is
thought to represent the fatty mutation (fa). Amino acid sequence alignments are presented
for human, rat and mouse OB-R.
Abstract
The discovery of leptin, a peptide hormone synthesized in adipocytes, has led to the identification of a novel signal transduction pathway involved in the control of body weight. This letter describes a missense mutation in the rat leptin receptor gene (OB-R) that is thought to represent the fatty mutation (fa). Amino acid sequence alignments are presented for human, rat and mouse OB-R.
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