Cardiorespiratory responses to intracerebroventricular injection of neuropeptide Y in anaesthetised dogs
KDR Morton, MJD McCloskey, EK Potter - Regulatory peptides, 1999 - Elsevier
Cardiovascular and respiratory effects of intracerebroventricular (icv) administration of
neuropeptide Y (NPY) and separate, preferential agonists for NPY Y1 and Y2 receptors
were observed in anaesthetised dogs. Central injections of NPY resulted in significant
cardiac slowing and decreases in arterial pressure. These cardiovascular effects were
blocked by central injection of the NPY Y1-preferring antagonist 1229U91. Central injection
of NPY did not have a significant effect on ventilation, but the NPY Y1 antagonist 1229U91 …
neuropeptide Y (NPY) and separate, preferential agonists for NPY Y1 and Y2 receptors
were observed in anaesthetised dogs. Central injections of NPY resulted in significant
cardiac slowing and decreases in arterial pressure. These cardiovascular effects were
blocked by central injection of the NPY Y1-preferring antagonist 1229U91. Central injection
of NPY did not have a significant effect on ventilation, but the NPY Y1 antagonist 1229U91 …