Duodenal metal-transporter (DMT-1, NRAMP-2) expression in patients with hereditary haemochromatosis
H Zoller, A Pietrangelo, W Vogel, G Weiss - The Lancet, 1999 - thelancet.com
H Zoller, A Pietrangelo, W Vogel, G Weiss
The Lancet, 1999•thelancet.comBackground Although the gene for hereditary haemochromatosis has been cloned, the
mechanism by which iron uptake is inappropriately increased in this disorder is unclear. Iron
absorption is regulated by the duodenal metal transporter, DMT-1, also called NRAMP-2 We
investigated the expression of NRAMP-2 in patients with hereditary haemochromatosis.
Methods Duodenal biopsy samples were taken from 20 patients with haemochromatosis
homozygous for the C282Y mutation and from ten controls. NRAMP-2 expression was …
mechanism by which iron uptake is inappropriately increased in this disorder is unclear. Iron
absorption is regulated by the duodenal metal transporter, DMT-1, also called NRAMP-2 We
investigated the expression of NRAMP-2 in patients with hereditary haemochromatosis.
Methods Duodenal biopsy samples were taken from 20 patients with haemochromatosis
homozygous for the C282Y mutation and from ten controls. NRAMP-2 expression was …
Summary
Background
Although the gene for hereditary haemochromatosis has been cloned, the mechanism by which iron uptake is inappropriately increased in this disorder is unclear. Iron absorption is regulated by the duodenal metal transporter, DMT-1, also called NRAMP-2 We investigated the expression of NRAMP-2 in patients with hereditary haemochromatosis.
Methods
Duodenal biopsy samples were taken from 20 patients with haemochromatosis homozygous for the C282Y mutation and from ten controls. NRAMP-2 expression was assessed by northern blotting and competitive PCR. NRAMP-2 mRNA was sequenced in seven patients and two controls.
thelancet.com