Clinical applications of angiogenic growth factors and their inhibitors
N Ferrara, K Alitalo - Nature medicine, 1999 - nature.com
N Ferrara, K Alitalo
Nature medicine, 1999•nature.comPromoting the formation of new collateral vessels in ischemic tissues using angiogenic
growth factors (therapeutic angiogenesis) is a an exciting frontier of cardiovascular
medicine. Conversely, inhibition of the action of key regulators of angiogenesis, such as
VEGF, constitutes a promising approach for the treatment of solid tumors and intraocular
neovascular syndromes. These concepts are being tested now in clinical trials.
growth factors (therapeutic angiogenesis) is a an exciting frontier of cardiovascular
medicine. Conversely, inhibition of the action of key regulators of angiogenesis, such as
VEGF, constitutes a promising approach for the treatment of solid tumors and intraocular
neovascular syndromes. These concepts are being tested now in clinical trials.
Abstract
Promoting the formation of new collateral vessels in ischemic tissues using angiogenic growth factors (therapeutic angiogenesis) is a an exciting frontier of cardiovascular medicine. Conversely, inhibition of the action of key regulators of angiogenesis, such as VEGF, constitutes a promising approach for the treatment of solid tumors and intraocular neovascular syndromes. These concepts are being tested now in clinical trials.
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