Antiangiogenic therapy of a recurrent giant cell tumor of the mandible with interferon alfa-2a
LB Kaban, JB Mulliken, RA Ezekowitz, D Phil… - …, 1999 - publications.aap.org
We report a 5-year-old girl with a large rapidly growing giant cell tumor of the mandible that
recurred 2 months after the first surgical excision and 3 months after a second resection. An
angiogenic protein,(bFGF), was abnormally elevated in her urine. The patient was treated
with interferon alfa-2a for 1 year because this agent inhibits angiogenesis by suppressing
bFGF overexpression in infantile hemangiomas and in other human tumors. During this time
the bone tumor regressed and disappeared, the urinary bFGF fell to normal levels, and the …
recurred 2 months after the first surgical excision and 3 months after a second resection. An
angiogenic protein,(bFGF), was abnormally elevated in her urine. The patient was treated
with interferon alfa-2a for 1 year because this agent inhibits angiogenesis by suppressing
bFGF overexpression in infantile hemangiomas and in other human tumors. During this time
the bone tumor regressed and disappeared, the urinary bFGF fell to normal levels, and the …