[HTML][HTML] Reactive nitrogen intermediates promote low density lipoprotein oxidation in human atherosclerotic intima
C Leeuwenburgh, MM Hardy, SL Hazen… - Journal of Biological …, 1997 - ASBMB
Oxidized low density lipoprotein (LDL) may be of central importance in triggering
atherosclerosis. One potential pathway involves the production of nitric oxide (NO) by
vascular wall endothelial cells and macrophages. NO reacts with superoxide to form
peroxynitrite (ONOO−), a potent agent of LDL oxidation in vitro. ONOO− nitrates the aromatic
ring of free tyrosine to produce 3-nitrotyrosine, a stable product. To explore the role of
reactive nitrogen species such as ONOO− in the pathogenesis of vascular disease, we …
atherosclerosis. One potential pathway involves the production of nitric oxide (NO) by
vascular wall endothelial cells and macrophages. NO reacts with superoxide to form
peroxynitrite (ONOO−), a potent agent of LDL oxidation in vitro. ONOO− nitrates the aromatic
ring of free tyrosine to produce 3-nitrotyrosine, a stable product. To explore the role of
reactive nitrogen species such as ONOO− in the pathogenesis of vascular disease, we …