Tumor suppressor activity of the TGF-β pathway in human cancers
SD Markowitz, AB Roberts - Cytokine & growth factor reviews, 1996 - Elsevier
The TGF-βs are a family of cytokines with antiproliferative activity on many cell types. Recent
findings demonstrate that the TGF-β receptor complex functions as a tumor suppressor gene
in human malignancy. Somatic mutations of the type II subunit of the TGF-β receptor (RII)
have been demonstrated in several different tumor types. RII frameshift mutations within a
short coding region polyadenine repeat are particularly characteristic of colon and gastric
cancers that also demonstrate the phenotype of microsatellite instability (RER cancers) …
findings demonstrate that the TGF-β receptor complex functions as a tumor suppressor gene
in human malignancy. Somatic mutations of the type II subunit of the TGF-β receptor (RII)
have been demonstrated in several different tumor types. RII frameshift mutations within a
short coding region polyadenine repeat are particularly characteristic of colon and gastric
cancers that also demonstrate the phenotype of microsatellite instability (RER cancers) …