Induction of chemotactic cytokines by minimally oxidized LDL
JA Berliner, DS Schwartz, MC Territo, A Andalibi… - … Chemokines: Biology of …, 1993 - Springer
JA Berliner, DS Schwartz, MC Territo, A Andalibi, L Almada, AJ Lusis, D Quismorio, ZP Fang…
The Chemokines: Biology of the Inflammatory Peptide Supergene Family II, 1993•SpringerAn important initiating event in atherogenesis is the entry of monocytes into the vessel wall.
In cholesterol fed animals after approximately one week of feeding, monocytes begin to bind
to the vessel wall and migrate into the subendothelial space (1, 2). Here they take up lipid
and form foam cells. Monocyte binding occurs only in certain areas of the vessel referred to
as areas of prediliction (3). In these areas liproteins accumulate (4), and several
investigators have shown that these lipoproteins are oxidized (5, 6). Our group has studied …
In cholesterol fed animals after approximately one week of feeding, monocytes begin to bind
to the vessel wall and migrate into the subendothelial space (1, 2). Here they take up lipid
and form foam cells. Monocyte binding occurs only in certain areas of the vessel referred to
as areas of prediliction (3). In these areas liproteins accumulate (4), and several
investigators have shown that these lipoproteins are oxidized (5, 6). Our group has studied …
Abstract
An important initiating event in atherogenesis is the entry of monocytes into the vessel wall. In cholesterol fed animals after approximately one week of feeding, monocytes begin to bind to the vessel wall and migrate into the subendothelial space (1,2). Here they take up lipid and form foam cells. Monocyte binding occurs only in certain areas of the vessel referred to as areas of prediliction (3). In these areas liproteins accumulate (4), and several investigators have shown that these lipoproteins are oxidized (5,6). Our group has studied the effects of minimally oxidized LDL (MM-LDL) on the interactions of monocytes with endothelial cells (7,8).
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