Adenosine 3′, 5′-monophosphate in pancreatic islets: glucose-induced insulin release
MA Charles, R Fanska, FG Schmid, PH Forsham… - Science, 1973 - science.org
MA Charles, R Fanska, FG Schmid, PH Forsham, GM Grodsky
Science, 1973•science.orgGlucose-induced release of insulin from perifused rat islets is associated with elevated islet
adenosine 3′, 5′-monophosphate. If values for adenosine 3′, 5′-monophosphate are
compared to insulin release during theophylline or glucose stimulation and theophylline
plus glucose stimulation, it suggests a minor role for adenosine 3′, 5′-monophosphate in
directly stimulating insulin release but a prominent role in modulating glucose-induced
release of insulin.
adenosine 3′, 5′-monophosphate. If values for adenosine 3′, 5′-monophosphate are
compared to insulin release during theophylline or glucose stimulation and theophylline
plus glucose stimulation, it suggests a minor role for adenosine 3′, 5′-monophosphate in
directly stimulating insulin release but a prominent role in modulating glucose-induced
release of insulin.
Glucose-induced release of insulin from perifused rat islets is associated with elevated islet adenosine 3′,5′-monophosphate. If values for adenosine 3′,5′-monophosphate are compared to insulin release during theophylline or glucose stimulation and theophylline plus glucose stimulation, it suggests a minor role for adenosine 3′,5′-monophosphate in directly stimulating insulin release but a prominent role in modulating glucose-induced release of insulin.
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