Proglucagon processing in islet and intestinal cell lines
JD Tucker, S Dhanvantari, PL Brubaker - Regulatory peptides, 1996 - Elsevier
To investigate the factors involved in the post-translational processing of proglucagon, we
have examined the proglucagon-derived peptides (PGDPs) expressed in normal mouse
pancreas and intestine, as well as in both islet (InR1-G9, RIN 1056A) and intestinal (STC-1)
cell lines. N-terminal proglucagon processing was similar to that of normal mouse pancreas
in InR1-G9 cells, but differed in RIN 1056A and STC-1 cells, which contained significant
amounts of glucagon as well as the intestinal PGDPs, glicentin and oxyntomodulin. The C …
have examined the proglucagon-derived peptides (PGDPs) expressed in normal mouse
pancreas and intestine, as well as in both islet (InR1-G9, RIN 1056A) and intestinal (STC-1)
cell lines. N-terminal proglucagon processing was similar to that of normal mouse pancreas
in InR1-G9 cells, but differed in RIN 1056A and STC-1 cells, which contained significant
amounts of glucagon as well as the intestinal PGDPs, glicentin and oxyntomodulin. The C …