Production of both 92-and 72-kDa gelatinases by bone cells
JA Lorenzo, CC Pilbeam, JF Kalinowski, MS Hibbs - Matrix, 1992 - Elsevier
We investigated the ability of murine bone organ cultures and osteoblast-like bone cells to
produce 72-and 92-kDa gelatinase. 4-6 day newborn mouse calvaria cultures were found to
release gelatinase activity into their conditioned medium (CM). This activity was increased
by four stimulators of resorption, tumor necrosis factor alpha (TNF), interleukin-1 alpha (IL-1),
parathyroid hormone (PTH) and the active phorbol ester, 12-0-tetradecanoylphorbol-
13acetate (TPA). Both the 72-and 92-kDa forms of gelatinase were produced by murine …
produce 72-and 92-kDa gelatinase. 4-6 day newborn mouse calvaria cultures were found to
release gelatinase activity into their conditioned medium (CM). This activity was increased
by four stimulators of resorption, tumor necrosis factor alpha (TNF), interleukin-1 alpha (IL-1),
parathyroid hormone (PTH) and the active phorbol ester, 12-0-tetradecanoylphorbol-
13acetate (TPA). Both the 72-and 92-kDa forms of gelatinase were produced by murine …