Phosphorylation and activation of a high molecular weight form of phospholipase A2 by p42 microtubule-associated protein 2 kinase and protein kinase C.
RA Nemenoff, S Winitz, NX Qian, V Van Putten… - Journal of Biological …, 1993 - ASBMB
Phospholipase A2 (PLA2) is the enzyme regulating the release of arachidonic acid in most
cell types. A high molecular mass, 85-kDa soluble form of PLA2 (cPLA2) has recently been
identified, the activity of which is stably increased by stimulation of cells with hormones and
growth factors. Growth factor stimulation of cells has been reported to result in increased
phosphorylation of cPLA2 on serine residues, but the kinases mediating this effect have not
been identified. We report here that human cPLA2 is phosphorylated in vitro by two growth …
cell types. A high molecular mass, 85-kDa soluble form of PLA2 (cPLA2) has recently been
identified, the activity of which is stably increased by stimulation of cells with hormones and
growth factors. Growth factor stimulation of cells has been reported to result in increased
phosphorylation of cPLA2 on serine residues, but the kinases mediating this effect have not
been identified. We report here that human cPLA2 is phosphorylated in vitro by two growth …