[HTML][HTML] Oncogenic src, raf, and rasStimulate a Hypertrophic Pattern of Gene Expression and Increase Cell Size in Neonatal Rat Ventricular Myocytes
SJ Fuller, J Gillespie-Brown, PH Sugden - Journal of Biological Chemistry, 1998 - ASBMB
In response to hormones and growth factors, cultured neonatal ventricular myocytes
increase in profile, exhibit myofibrillogenesis, and re-express genes whose expression is
normally restricted to the fetal stage of ventricular development. These include atrial
natriuretic factor (ANF), β-myosin heavy chain (β-MHC), and skeletal muscle (SkM)-α-actin.
By using luciferase reporter plasmids, we examined whether oncogenes that activate the
extracellular signal-regulated kinase cascade (src F527, Ha-ras V12, and v-raf) increased …
increase in profile, exhibit myofibrillogenesis, and re-express genes whose expression is
normally restricted to the fetal stage of ventricular development. These include atrial
natriuretic factor (ANF), β-myosin heavy chain (β-MHC), and skeletal muscle (SkM)-α-actin.
By using luciferase reporter plasmids, we examined whether oncogenes that activate the
extracellular signal-regulated kinase cascade (src F527, Ha-ras V12, and v-raf) increased …