Cytolysis of adenovirus-infected murine fibroblasts by IFN-γ-primed macrophages is TNF-and contact-dependent
DB Day, NA Zachariades, LR Gooding - Cellular immunology, 1994 - Elsevier
The effect of interferon-γ (IFN-γ) priming on macrophages for cytolysis of adenovirus-infected
murine fibroblasts was examined using peritoneal macrophages and the RAW264. 7 (RAW)
murine macrophage cell line. Adenovirus-infected cells were lysed by IFN-γ-primed RAW
macrophages via a TNF-and contact-dependent mechanism under conditions in which little
or no soluble TNF was detected in the supernatant of these effectors. TNF involvement in the
lytic mechanism of IFN-γ-primed macrophages is shown by (a) cytolysis of TNF-sensitive LM …
murine fibroblasts was examined using peritoneal macrophages and the RAW264. 7 (RAW)
murine macrophage cell line. Adenovirus-infected cells were lysed by IFN-γ-primed RAW
macrophages via a TNF-and contact-dependent mechanism under conditions in which little
or no soluble TNF was detected in the supernatant of these effectors. TNF involvement in the
lytic mechanism of IFN-γ-primed macrophages is shown by (a) cytolysis of TNF-sensitive LM …