[HTML][HTML] Melanocortin receptors in leptin effects
Nature, 1997•nature.com
Leptin acts on the central nervous system to cause a reduction in food intake and body
weight,. The melanocortin system in the brain is also implicated in energy homeostasis, with
agonists of the melanocortin-4 (MC4) receptor reducing food intake and targeted mutation of
the MC4 receptor causing obesity. We now show that MC4 receptor signalling is an
important mediator of leptin's effects on food intake and body weight, demonstrating a link
between the two systems.
weight,. The melanocortin system in the brain is also implicated in energy homeostasis, with
agonists of the melanocortin-4 (MC4) receptor reducing food intake and targeted mutation of
the MC4 receptor causing obesity. We now show that MC4 receptor signalling is an
important mediator of leptin's effects on food intake and body weight, demonstrating a link
between the two systems.
Abstract
Leptin acts on the central nervous system to cause a reduction in food intake and body weight,. The melanocortin system in the brain is also implicated in energy homeostasis, with agonists of the melanocortin-4 (MC4) receptor reducing food intake and targeted mutation of the MC4 receptor causing obesity. We now show that MC4 receptor signalling is an important mediator of leptin's effects on food intake and body weight, demonstrating a link between the two systems.
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