Atypical xanthomatosis in apolipoprotein E-deficient mice after cholesterol feeding
JH van Ree, MJJ Gijbels, WJAA van den Broek… - Atherosclerosis, 1995 - Elsevier
Apolipoprotein (apo) E-deficient mice were fed a hypercholesterolemic diet for 14 weeks.
Mean serum cholesterol levels rose to 37.5 mM. Upon complete necroscopy, massive
xanthomatous lesions were noticed in various tissues, with a predilection for subcutaneous
and peritendinous tissues, while control animals on the same diet (3.4 mM serum
cholesterol) and apo E-deficient mice on a regular chow diet (20 mM serum cholesterol) did
not show such lesions. Also, apo E3-Leiden transgenic mice fed a high fat diet, with 60 mM …
Mean serum cholesterol levels rose to 37.5 mM. Upon complete necroscopy, massive
xanthomatous lesions were noticed in various tissues, with a predilection for subcutaneous
and peritendinous tissues, while control animals on the same diet (3.4 mM serum
cholesterol) and apo E-deficient mice on a regular chow diet (20 mM serum cholesterol) did
not show such lesions. Also, apo E3-Leiden transgenic mice fed a high fat diet, with 60 mM …