ACAT inhibitors CL 283,546 and CL 283,796 reduce LDL cholesterol without affecting cholesterol absorption in African green monkeys.
SM Wrenn, JS Parks, FW Immermann, LL Rudel - Journal of lipid research, 1995 - ASBMB
Previous studies with a number of selective acylcoenzyme A: cholesterol acyltransferase
(ACAT) inhibitors in several animal models have demonstrated significant reductions in
plasma cholesterol and, in some studies, triglyceride levels. This study was conducted to
examine the effects of two ACAT inhibitors, CL 283,546 and CL 283,796, in cholesterol-high
fat diet fed African green monkeys, a relevant primate model of hyperlipidemia and coronary
artery atherosclerosis. Treatment with CL 283,546 or CL 283,796 resulted in significant …
(ACAT) inhibitors in several animal models have demonstrated significant reductions in
plasma cholesterol and, in some studies, triglyceride levels. This study was conducted to
examine the effects of two ACAT inhibitors, CL 283,546 and CL 283,796, in cholesterol-high
fat diet fed African green monkeys, a relevant primate model of hyperlipidemia and coronary
artery atherosclerosis. Treatment with CL 283,546 or CL 283,796 resulted in significant …