Promoter sequences of the human transforming growth factor-β1 gene responsive to transforming growth factor-β1 autoinduction
SJ Kim, KT Jeang, AB Glick, MB Sporn… - Journal of Biological …, 1989 - ASBMB
Two distinct regions of the transforming growth factor (TGF)-β1 promoter are responsive to
autoregulation. Sequences located between nucleotides− 454 to− 323 and between the two
major transcriptional start sites have positive regulatory activities and are induced by TGF-β1
in A-549 cells. The chloramphenicol acetyltransferase activity of the upstream human TGF-
β1 promoter-chloramphenicol acetyltransferase gene is increased 8-to 10-fold by treatment
of cells with TGF-β1, whereas that of the second promoter is increased approximately 3-to 4 …
autoregulation. Sequences located between nucleotides− 454 to− 323 and between the two
major transcriptional start sites have positive regulatory activities and are induced by TGF-β1
in A-549 cells. The chloramphenicol acetyltransferase activity of the upstream human TGF-
β1 promoter-chloramphenicol acetyltransferase gene is increased 8-to 10-fold by treatment
of cells with TGF-β1, whereas that of the second promoter is increased approximately 3-to 4 …