[HTML][HTML] Egr-1 activates basic fibroblast growth factor transcription: mechanistic implications for astrocyte proliferation
E Biesiada, M Razandi, ER Levin - Journal of biological chemistry, 1996 - ASBMB
The mechanisms controlling the proliferation of astrocytes are of great interest but are not
well defined. We have previously shown that the endogenous neuropeptides, endothelin-3
(ET-3), and atrial natriuretic peptide (ANP), modulate the proliferation of astrocytes through
positively and negatively regulating the transcription of the immediate-early gene egr-1
which transactivates basic fibroblast growth factor (bFGF) by unknown mechanisms. In these
studies, we determined the involvement of MAP kinase (Erk) activation by ET-3 in the …
well defined. We have previously shown that the endogenous neuropeptides, endothelin-3
(ET-3), and atrial natriuretic peptide (ANP), modulate the proliferation of astrocytes through
positively and negatively regulating the transcription of the immediate-early gene egr-1
which transactivates basic fibroblast growth factor (bFGF) by unknown mechanisms. In these
studies, we determined the involvement of MAP kinase (Erk) activation by ET-3 in the …