Vascular endothelium forms a continuous cellular interface between the circulating blood
elements and the surrounding tissues. Endothelium forms a nonthrombogenic surface and
selective permeability barrier capable of modulating vascular reactivity and blood flow. The
integrity of the endothelium is fundamental for the maintenance of normal homeostasis.
Injury to this lining results in dramatic changes in the functional characteristics of the
endothelium, rendering it adhesive and prothrombotic. These changes may result from …