[HTML][HTML] Basolateral localization of fiber receptors limits adenovirus infection from the apical surface of airway epithelia
RW Walters, T Grunst, JM Bergelson… - Journal of Biological …, 1999 - ASBMB
Recent identification of two receptors for the adenovirus fiber protein, coxsackie B and
adenovirus type 2 and 5 receptor (CAR), and the major histocompatibility complex (MHC)
Class I α-2 domain allows the molecular basis of adenoviral infection to be investigated.
Earlier work has shown that human airway epithelia are resistant to infection by adenovirus.
Therefore, we examined the expression and localization of CAR and MHC Class I in an in
vitro model of well differentiated, ciliated human airway epithelia. We found that airway …
adenovirus type 2 and 5 receptor (CAR), and the major histocompatibility complex (MHC)
Class I α-2 domain allows the molecular basis of adenoviral infection to be investigated.
Earlier work has shown that human airway epithelia are resistant to infection by adenovirus.
Therefore, we examined the expression and localization of CAR and MHC Class I in an in
vitro model of well differentiated, ciliated human airway epithelia. We found that airway …