Polarized sorting of GPI-linked proteins in epithelia and membrane microdomains
MP Lisanti, E Rodriguez-Boulan - Cell biology international reports, 1991 - Elsevier
Taken together, our results with endogenous and transfected GPI-anchored proteins
(summarized in Table 6) suggest that covalent attachment to GPI functions as an apical
transport signal in polarized epithelial cells. This is the first example of a well-defined
targeting signal for the post-Golgi sorting of plasma membrane proteins in polarized
epithelia; the only other known post-Golgi targeting signal is mannose-6-phosphate, which
functions in the recognition of lysosomal hydrolases and directs them to lysosomes.
(summarized in Table 6) suggest that covalent attachment to GPI functions as an apical
transport signal in polarized epithelial cells. This is the first example of a well-defined
targeting signal for the post-Golgi sorting of plasma membrane proteins in polarized
epithelia; the only other known post-Golgi targeting signal is mannose-6-phosphate, which
functions in the recognition of lysosomal hydrolases and directs them to lysosomes.