[PDF][PDF] Targeting Of adenovirus penton base to new receptors through replacement of its FGD motif with other
TJ Wickham, ME Carrion, I Kovesdi - Gene therapy, 1995 - researchgate.net
Penton base is a pentamer coat protein from adenovirus containing five copies of the
integrin receptor binding motif, arg-gly-asp (RGD), which is used by the virus to bind the
integrins o, B, and o, B, Following adenovirus attachment to cells via its fiber coat protein, the
integrin receptors then mediate virus internalization into the host cells. The RGD sequence
is required for integrin binding since interaction of penton base with integrins is blocked by
RGD peptides and in penton base mutants containing the sequence RGE. The RGD region …
integrin receptor binding motif, arg-gly-asp (RGD), which is used by the virus to bind the
integrins o, B, and o, B, Following adenovirus attachment to cells via its fiber coat protein, the
integrin receptors then mediate virus internalization into the host cells. The RGD sequence
is required for integrin binding since interaction of penton base with integrins is blocked by
RGD peptides and in penton base mutants containing the sequence RGE. The RGD region …