Biphasic kinetics of peripheral blood T cells after triple combination therapy in HIV-1 infection: a composite of redistribution and proliferation

NG Pakker, DW Notermans, RJ De Boer, MTL Roos… - Nature medicine, 1998 - nature.com
NG Pakker, DW Notermans, RJ De Boer, MTL Roos, FD Wolf, A Hill, JM Leonard, SA Danner…
Nature medicine, 1998nature.com
The origin of CD4+ T cells reappearing in the blood following antiretroviral therapy in human
immunodeficiency virus type-1 (HIV-1) infection is still controversial. Here we show, using
mathematical modeling, that redistribution of T cells to the blood can explain the striking
correlation between the initial CD4+ and CD8+ memory T-cell repopulation and the
observation that 3 weeks after the start of treatment memory CD4+ T-cell numbers reach a
plateau. The increase in CD4+ T cells following therapy most likely is a composite of initial …
Abstract
The origin of CD4+ T cells reappearing in the blood following antiretroviral therapy in human immunodeficiency virus type-1 (HIV-1) infection is still controversial. Here we show, using mathematical modeling, that redistribution of T cells to the blood can explain the striking correlation between the initial CD4+ and CD8+ memory T-cell repopulation and the observation that 3 weeks after the start of treatment memory CD4+ T-cell numbers reach a plateau. The increase in CD4+ T cells following therapy most likely is a composite of initial redistribution, accompanied by a continuous slow repopulation with newly produced naive T cells.
nature.com