Attenuation of plasma low density lipoprotein cholesterol by select 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors in mice devoid of low density …
CL Bisgaier, AD Essenburg, BJ Auerbach… - Journal of lipid …, 1997 - ASBMB
Low density lipoprotein (LDL) reduction independent of LDL receptor regulation was
investigated using HMG-CoA reductase inhibitors in LDL receptor-deficient mice. In males,
LDL cholesterol dose-dependently decreased with atorvastatin treatment after 1 week. As
untreated mice grew older, their LDL cholesterol progressively rose above basal levels, but
was quelled with atorvastatin treatment. In females, atorvastatin treatment time-dependently
decreased LDL cholesterol levels and induced hepatic HMG-CoA reductase activity. Unlike …
investigated using HMG-CoA reductase inhibitors in LDL receptor-deficient mice. In males,
LDL cholesterol dose-dependently decreased with atorvastatin treatment after 1 week. As
untreated mice grew older, their LDL cholesterol progressively rose above basal levels, but
was quelled with atorvastatin treatment. In females, atorvastatin treatment time-dependently
decreased LDL cholesterol levels and induced hepatic HMG-CoA reductase activity. Unlike …