RAP, a novel type of ER chaperone

G Bu, AL Schwartz - Trends in cell biology, 1998 - cell.com
G Bu, AL Schwartz
Trends in cell biology, 1998cell.com
Members of the low-density lipoprotein (LDL) receptor gene family play an important role in
cellular uptake of various extracellular ligands. Recent studies have shown that a 39-kDa
protein known as RAP (receptor-associated protein) serves as a molecular chaperone to
assist the folding of certain LDL-receptor family proteins and their passage through the
secretory pathway. In this review, the authors discuss our current understanding of the roles
of RAP as a molecular chaperone/escort protein and present a model of how RAP might …
Abstract
Members of the low-density lipoprotein (LDL) receptor gene family play an important role in cellular uptake of various extracellular ligands. Recent studies have shown that a 39-kDa protein known as RAP (receptor-associated protein) serves as a molecular chaperone to assist the folding of certain LDL-receptor family proteins and their passage through the secretory pathway. In this review, the authors discuss our current understanding of the roles of RAP as a molecular chaperone/escort protein and present a model of how RAP might carry out these functions.
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