Purification of the apolipoprotein B-67-containing low density lipoprotein particle and its affinity for the low density lipoprotein receptor.
FK Welty, L Seman, FT Yen - Journal of lipid research, 1995 - ASBMB
Naturally occurring mutant forms of apolipoprotein B (apoB)-100 may be able to provide
valuable information on the structure-function relationships of apoB with the low density
lipoprotein (LDL) receptor. ApoB-67, recently identified in a kindred displaying apoB levels
25% of normal (Welty et al. J. Clin. Invest. 1991. 87: 1748-1754), is predicted to contain 3040
amino acids and therefore, contains part of the epitope for antibody 4G3, which blocks
binding of LDL to the LDL-receptor. To determine whether the amino terminal 67% of apoB …
valuable information on the structure-function relationships of apoB with the low density
lipoprotein (LDL) receptor. ApoB-67, recently identified in a kindred displaying apoB levels
25% of normal (Welty et al. J. Clin. Invest. 1991. 87: 1748-1754), is predicted to contain 3040
amino acids and therefore, contains part of the epitope for antibody 4G3, which blocks
binding of LDL to the LDL-receptor. To determine whether the amino terminal 67% of apoB …