[HTML][HTML] Differential regulation of apolipoprotein B secretion from HepG2 cells by two HMG-CoA reductase inhibitors, atorvastatin and simvastatin

LJ Wilcox, PHR Barrett, MW Huff - Journal of lipid research, 1999 - ASBMB
The concept that hepatic cholesterol synthesis regulates hepatocyte assembly and secretion
of apoB-containing lipoproteins remains controversial. The present study was carried out in
HepG2 cells to examine the regulation of apoB secretion by the HMG-CoA reductase
inhibitor atorvastatin. ApoB accumulation in the media was decreased by 24% and 36% at
10 μm (P< 0.02) and 20 μm (P< 0.01) of atorvastatin, respectively. Atorvastatin inhibited
HepG2 cell cholesterol synthesis by up to 96%(P< 0.001) and cellular cholesteryl ester (CE) …