Comparative effects of HMG-CoA reductase inhibitors on apo B production in the casein-fed rabbit: atorvastatin versus lovastatin
BJ Auerbach, BR Krause, CL Bisgaier, RS Newton - Atherosclerosis, 1995 - Elsevier
Rabbits fed a diet enriched in casein develop an endogenous hypercholesterolemia (EH)
due both to an increased low density lipoprotein (LDL) synthetic rate and decreased LDL
receptor activity. Pre-established EH in this model was used to assess the ability and
mechanism by which atorvastatin lowers total plasma cholesterol (TPC) compared to the
reference agent lovastatin. Rabbits were fed a casein diet for 6 weeks, obtaining average
TPC levels above 200 mg/dl. To ensure equivalent mean cholesterol concentrations …
due both to an increased low density lipoprotein (LDL) synthetic rate and decreased LDL
receptor activity. Pre-established EH in this model was used to assess the ability and
mechanism by which atorvastatin lowers total plasma cholesterol (TPC) compared to the
reference agent lovastatin. Rabbits were fed a casein diet for 6 weeks, obtaining average
TPC levels above 200 mg/dl. To ensure equivalent mean cholesterol concentrations …