[HTML][HTML] Membrane expression of soluble endotoxin-binding proteins permits lipopolysaccharide signaling in Chinese hamster ovary fibroblasts independently of …
RR Ingalls, BG Monks, DT Golenbock - Journal of Biological Chemistry, 1999 - ASBMB
The activation of phagocytes by lipopolysaccharide (LPS) has been implicated in the
pathogenesis of Gram-negative sepsis. Although the interaction between CD14 and LPS is
a key event in the signaling cascade, the molecular mechanism by which cellular activation
occurs remains obscure. We hypothesized that the main function of CD14 was to bind LPS
and transfer it to a second receptor, which then initiates the subsequent signal for cellular
activation. Thus, surface binding of LPS to the cell membrane would be the critical step that …
pathogenesis of Gram-negative sepsis. Although the interaction between CD14 and LPS is
a key event in the signaling cascade, the molecular mechanism by which cellular activation
occurs remains obscure. We hypothesized that the main function of CD14 was to bind LPS
and transfer it to a second receptor, which then initiates the subsequent signal for cellular
activation. Thus, surface binding of LPS to the cell membrane would be the critical step that …