1, 25-Dihydroxyvitamin D3 modulates bone marrow macrophage precursor proliferation and differentiation. Up-regulation of the mannose receptor.
DR Clohisy, Z Bar-Shavit, JC Chappel… - Journal of Biological …, 1987 - ASBMB
1, 25-Dihydroxyvitamin D3 (1, 25−(OH) 2D3), the biologically active form of vitamin D3, has
been shown to inhibit proliferation and promote monocytic differentiation of leukemic cell
lines. In the present communication, we extend these observations to normal bone marrow
macrophage precursors, and 1) identify the stage of monocytic maturation wherein the
steroid exerts its antiproliferative effect, and 2) demonstrate that 1, 25−(OH) 2D3 promotes
bone marrow macrophage differentiation as manifest by specific up-regulation of the lineage …
been shown to inhibit proliferation and promote monocytic differentiation of leukemic cell
lines. In the present communication, we extend these observations to normal bone marrow
macrophage precursors, and 1) identify the stage of monocytic maturation wherein the
steroid exerts its antiproliferative effect, and 2) demonstrate that 1, 25−(OH) 2D3 promotes
bone marrow macrophage differentiation as manifest by specific up-regulation of the lineage …