Polymorphic imprinting of the serotonin-2A (5-HT2A) receptor gene in human adult brain
R Bunzel, I Blümcke, S Cichon, S Normann… - Molecular brain …, 1998 - Elsevier
We have examined the imprinting status of the serotonin-2A (5-HT2A) receptor gene
(HTR2A) in a series of 41 tissue samples from human adult brain. Using a HpaII RFLP
polymorphism in the coding region, we obtained evidence of monoallelic expression of
HTR2A in 4 out of 18 informative individuals. However, biallelic expression of HTR2A was
observed in other individuals (14/18), suggesting that within the human population HTR2A
imprinting in brain is polymorphic.
(HTR2A) in a series of 41 tissue samples from human adult brain. Using a HpaII RFLP
polymorphism in the coding region, we obtained evidence of monoallelic expression of
HTR2A in 4 out of 18 informative individuals. However, biallelic expression of HTR2A was
observed in other individuals (14/18), suggesting that within the human population HTR2A
imprinting in brain is polymorphic.