[HTML][HTML] CD95 (Fas/APO-1) induces ceramide formation and apoptosis in the absence of a functional acid sphingomyelinase
JGR Boesen-de Cock, AD Tepper, E de Vries… - Journal of Biological …, 1998 - ASBMB
CD95 is a potent inducer of apoptosis. It activates the caspase cascade, but also induces
ceramide (Cer) production, reportedly involving acid sphingomyelinase (aSMase) activity. A
role for Cer as a second messenger for apoptosis induction was proposed, based on the
finding that synthetic Cer analogues can induce cell death. We have tested whether aSMase
is required for 1) apoptosis induction and 2) Cer production by CD95. For this purpose, we
have used cultured Niemann-Pick disease (NPD) lymphoid cells with a defined mutation …
ceramide (Cer) production, reportedly involving acid sphingomyelinase (aSMase) activity. A
role for Cer as a second messenger for apoptosis induction was proposed, based on the
finding that synthetic Cer analogues can induce cell death. We have tested whether aSMase
is required for 1) apoptosis induction and 2) Cer production by CD95. For this purpose, we
have used cultured Niemann-Pick disease (NPD) lymphoid cells with a defined mutation …