[HTML][HTML] Insulin receptor substrate 3 is not essential for growth or glucose homeostasis
SCH Liu, Q Wang, GE Lienhard, SR Keller - Journal of Biological Chemistry, 1999 - ASBMB
The insulin receptor substrates (IRS) 1 and 2 are required for normal growth and glucose
homeostasis in mice. To determine whether IRS-3, a recently cloned member of the IRS
family, is also involved in the regulation of these, we have generated mice with a targeted
disruption of the IRS-3 gene and characterized them. Compared with wild-type mice, the IRS-
3-null mice showed normal body weight throughout development, normal blood glucose
levels in the fed and fasted state and following an oral glucose bolus, and normal fed and …
homeostasis in mice. To determine whether IRS-3, a recently cloned member of the IRS
family, is also involved in the regulation of these, we have generated mice with a targeted
disruption of the IRS-3 gene and characterized them. Compared with wild-type mice, the IRS-
3-null mice showed normal body weight throughout development, normal blood glucose
levels in the fed and fasted state and following an oral glucose bolus, and normal fed and …