[HTML][HTML] Increased High Density Lipoprotein (HDL), Defective Hepatic Catabolism of ApoA-I and ApoA-II, and Decreased ApoA-I mRNA inob/ob Mice: POSSIBLE …
Abnormalities of plasma high density lipoprotein (HDL) levels commonly reflect altered
metabolism of the major HDL apolipoproteins, apoA-I and apoA-II, but the regulation of
apolipoprotein metabolism is poorly understood. Two mouse models of obesity, ob/ob and
db/db, have markedly increased plasma HDL cholesterol levels. The purpose of this study
was to evaluate mechanisms responsible for increased HDL inob/ob mice and to assess
potential reversibility by leptin administration. ob/ob mice were found to have increased HDL …
metabolism of the major HDL apolipoproteins, apoA-I and apoA-II, but the regulation of
apolipoprotein metabolism is poorly understood. Two mouse models of obesity, ob/ob and
db/db, have markedly increased plasma HDL cholesterol levels. The purpose of this study
was to evaluate mechanisms responsible for increased HDL inob/ob mice and to assess
potential reversibility by leptin administration. ob/ob mice were found to have increased HDL …