Kinetics and physiologic relevance of the inactivation of alpha 1-proteinase inhibitor, alpha 1-antichymotrypsin, and antithrombin III by matrix metalloproteinases-1 …
AE Mast, JJ Enghild, H Nagase, K Suzuki… - Journal of Biological …, 1991 - ASBMB
Serpins encompass a superfamily of proteinase inhibitors that regulate many of the serine
proteinases involved in inflammation and hemostasis. In vitro, many serpins are catalytically
inactivated by proteinases that they do not inhibit, leading to the concept of proteolytic down-
regulation of serpin inhibitory capacity. The extent to which down-regulation of serpin activity
occurs in vivo is debated, since little is known of the rates at which the process occurs. To
address this debate, we have measured the rates of inactivation of three serpins, alpha 1 …
proteinases involved in inflammation and hemostasis. In vitro, many serpins are catalytically
inactivated by proteinases that they do not inhibit, leading to the concept of proteolytic down-
regulation of serpin inhibitory capacity. The extent to which down-regulation of serpin activity
occurs in vivo is debated, since little is known of the rates at which the process occurs. To
address this debate, we have measured the rates of inactivation of three serpins, alpha 1 …