Alloreactive T-cell clones identify multiple HLA-DQw3 variants
EM Mickelson, SA Masewicz, GT Nepom, PJ Martin… - Human immunology, 1991 - Elsevier
HLA-DQw3 is a broadly defined alloantigen that has been subdivided by serological,
biochemical, and molecular methods into three distinct specificities: DQw7, DQw8, and
DQw9. In order to characterize functionally relevant structural polymorphisms within this
family of alloantigens, we generated a series of DQw3-reactive T-cell clones that together
recognize six different variants of DQw3. T-cell clones IG11 and IG9 were found to recognize
three distinct functional variants associated with a majority of DQw3+ cells, while clones 2IJ …
biochemical, and molecular methods into three distinct specificities: DQw7, DQw8, and
DQw9. In order to characterize functionally relevant structural polymorphisms within this
family of alloantigens, we generated a series of DQw3-reactive T-cell clones that together
recognize six different variants of DQw3. T-cell clones IG11 and IG9 were found to recognize
three distinct functional variants associated with a majority of DQw3+ cells, while clones 2IJ …