Experimental staphylococcal toxic epidermal necrolysis (TEN) in adult humans and mice

PM Elias, P Fritsch, G Tappeiner… - The Journal of …, 1974 - translationalres.com
Newborn mice and young children are considered uniquely susceptible to staphylococcal
toxic epidermal necrolysis, while older humans and mice are presumably more resistant.
Twelve human volunteer subjects, injected intracutaneously with cell-free filtrates of phage
Group II staphylococci purified by (NH 4) 2 SO 4 precipitation and ion exchange
chromatography, developed spontaneous wrinkling or flaccid bullae over injection sites
within 1 12 to 2 hours, and/or histologic evidence of cleavage limited to the lower granular …