Fas-FasL interactions: a common pathogenetic mechanism in organ-specific autoimmunity
R De Maria, R Testi - Immunology today, 1998 - cell.com
Immunology today, 1998•cell.com
Organ-specific autoimmunity is characterized by the accelerated loss of selected cell types,
resulting in specific tissue destruction and disease. The role of different genetic or
environmental factors in initiating the autoimmune reactivity is still unclear. However, novel
mechanisms responsible for tissue destruction have recently been revealed. Here, Ruggero
De Maria and Roberto Testi propose that Fas ligand may represent a common weapon
during the destructive phase of organ-specific autoimmunity.
resulting in specific tissue destruction and disease. The role of different genetic or
environmental factors in initiating the autoimmune reactivity is still unclear. However, novel
mechanisms responsible for tissue destruction have recently been revealed. Here, Ruggero
De Maria and Roberto Testi propose that Fas ligand may represent a common weapon
during the destructive phase of organ-specific autoimmunity.
Abstract
Organ-specific autoimmunity is characterized by the accelerated loss of selected cell types, resulting in specific tissue destruction and disease. The role of different genetic or environmental factors in initiating the autoimmune reactivity is still unclear. However, novel mechanisms responsible for tissue destruction have recently been revealed. Here, Ruggero De Maria and Roberto Testi propose that Fas ligand may represent a common weapon during the destructive phase of organ-specific autoimmunity.
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