Host factors and the pathogenesis of HIV-induced disease

AS Fauci - Nature, 1996 - nature.com
Nature, 1996nature.com
The level of human immunodeficiency virus (HIV) replication in patients reflects a balance
between stimulatory and inhibitory host factors (particularly endogenous cytokines). New
information concerning the cellular co-receptors for HIV and the cellular tropism of different
strains of virus will advance our understanding of HIV-induced pathogenesis and suggests
new therapeutic and preventive strategies.
Abstract
The level of human immunodeficiency virus (HIV) replication in patients reflects a balance between stimulatory and inhibitory host factors (particularly endogenous cytokines). New information concerning the cellular co-receptors for HIV and the cellular tropism of different strains of virus will advance our understanding of HIV-induced pathogenesis and suggests new therapeutic and preventive strategies.
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