[HTML][HTML] Activation of Stimulus-Secretion Coupling in Pancreatic β-Cells by Specific Products of Glucose Metabolism: EVIDENCE FOR PRIVILEGED SIGNALING BY …
RJ Mertz, JF Worley, B Spencer, JH Johnson… - Journal of Biological …, 1996 - ASBMB
The energy requirements of most cells supplied with glucose are fulfilled by glycolytic and
oxidative metabolism, yielding ATP. In pancreatic β-cells, a rise in cytosolic ATP is also a
critical signaling event, coupling closure of ATP-sensitive K+ channels (K ATP) to insulin
secretion via depolarization-driven increases in intracellular Ca 2+([Ca 2+] j). We report that
glycolytic but not Krebs cycle metabolism of glucose is critically involved in this signaling
process. While inhibitors of glycolysis suppressed glucose-stimulated insulin secretion …
oxidative metabolism, yielding ATP. In pancreatic β-cells, a rise in cytosolic ATP is also a
critical signaling event, coupling closure of ATP-sensitive K+ channels (K ATP) to insulin
secretion via depolarization-driven increases in intracellular Ca 2+([Ca 2+] j). We report that
glycolytic but not Krebs cycle metabolism of glucose is critically involved in this signaling
process. While inhibitors of glycolysis suppressed glucose-stimulated insulin secretion …