Brain natriuretic peptide is induced by alpha 1-adrenergic agonists as a primary response gene in cultured rat cardiac myocytes
DS Hanford, DJ Thuerauf, SF Murray… - Journal of Biological …, 1994 - ASBMB
To better understand the molecular basis for increased atrial natriuretic factor (ANF) and
brain natriuretic peptide (BNP) expression during overload-induced cardiac hypertrophy, we
studied the induction of the genes in primary myocardial cells by the alpha 1-adrenergic
agonist, phenylephrine (PE), a potent hypertrophic agent. PE augmented the transcription of
both genes to similar extents, although the time course of mRNA accumulation differed.
Increases in ANF mRNA were evident only after 6-8 h of PE exposure, when transcript levels …
brain natriuretic peptide (BNP) expression during overload-induced cardiac hypertrophy, we
studied the induction of the genes in primary myocardial cells by the alpha 1-adrenergic
agonist, phenylephrine (PE), a potent hypertrophic agent. PE augmented the transcription of
both genes to similar extents, although the time course of mRNA accumulation differed.
Increases in ANF mRNA were evident only after 6-8 h of PE exposure, when transcript levels …