[HTML][HTML] p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways are required for nuclear factor-κB p65 transactivation mediated by …
WV Berghe, S Plaisance, E Boone… - Journal of Biological …, 1998 - ASBMB
Interleukin-6 (IL-6) is a pleiotropic cytokine, which is involved in inflammatory and immune
responses, acute phase reactions, and hematopoiesis. In the mouse fibrosarcoma cell line
L929, the nuclear factor (NF)-κB plays a crucial role in IL-6 gene expression mediated by
tumor necrosis factor (TNF). The levels of the activated factor do not, however, correlate with
the variations of IL-6 gene transcription; therefore, other factors and/or regulatory
mechanisms presumably modulate the levels of IL-6 mRNA production. Upon analysis of …
responses, acute phase reactions, and hematopoiesis. In the mouse fibrosarcoma cell line
L929, the nuclear factor (NF)-κB plays a crucial role in IL-6 gene expression mediated by
tumor necrosis factor (TNF). The levels of the activated factor do not, however, correlate with
the variations of IL-6 gene transcription; therefore, other factors and/or regulatory
mechanisms presumably modulate the levels of IL-6 mRNA production. Upon analysis of …