[HTML][HTML] Mammalian mitogen-activated protein kinase pathways are regulated through formation of specific kinase-activator complexes
BW Zanke, EA Rubie, E Winnett, J Chan… - Journal of Biological …, 1996 - ASBMB
Mammalian cells contain at least three signaling systems which are structurally related to the
mitogen-activated protein kinase (MAPK) pathway. Growth factors acting through Ras
primarily stimulate the Raf/MEK/MAPK cascade of protein kinases. In contrast, many stress-
related signals such as heat shock, inflammatory cytokines, and hyperosmolarity induce the
MEKK/SEK (MKK4)/SAPK (JNK) and/or the MKK3 or MKK6/p38 hog pathways. Physiological
agonists of these pathway types are either qualitatively or quantitatively distinct, suggesting …
mitogen-activated protein kinase (MAPK) pathway. Growth factors acting through Ras
primarily stimulate the Raf/MEK/MAPK cascade of protein kinases. In contrast, many stress-
related signals such as heat shock, inflammatory cytokines, and hyperosmolarity induce the
MEKK/SEK (MKK4)/SAPK (JNK) and/or the MKK3 or MKK6/p38 hog pathways. Physiological
agonists of these pathway types are either qualitatively or quantitatively distinct, suggesting …