[HTML][HTML] The mitogen-activated protein kinase kinase MEK1 stimulates a pattern of gene expression typical of the hypertrophic phenotype in rat ventricular …
J Gillespie-Brown, SJ Fuller, MA Bogoyevitch… - Journal of Biological …, 1995 - ASBMB
Adult mammalian ventricular cardiomyocytes are terminally differentiated cells that enlarge
adaptively by hypertrophy. In this situation, genes normally expressed in the fetal ventricular
cardiomyocyte (eg atrial natriuretic factor (ANF), β-myosin heavy chain (β-MHC), and
skeletal muscle (SkM) α-actin) are re-expressed, and there is transient expression of
immediate early genes (eg c-fos). Using appropriate reporter plasmids, we studied the
effects of transfection of the constitutively active or dominant negative mitogen-activated …
adaptively by hypertrophy. In this situation, genes normally expressed in the fetal ventricular
cardiomyocyte (eg atrial natriuretic factor (ANF), β-myosin heavy chain (β-MHC), and
skeletal muscle (SkM) α-actin) are re-expressed, and there is transient expression of
immediate early genes (eg c-fos). Using appropriate reporter plasmids, we studied the
effects of transfection of the constitutively active or dominant negative mitogen-activated …